The Basilica of Saint Paul Outside the Walls (San Paolo fuori le Mura) is the final resting place of St. Paul. The earliest structure over his burial site was created under Constantine in 324, and the church was rebuilt multiple times, including after a devastating fire in 1823. Decorations of Paul's life are throughout this, Rome's second largest church.

Michelangelo repurposed the ruins of Emperor Diocletian's baths into the church Santa Maria degli Angeli, where the massive scale of ancient structures is layered into a beautiful basilica. The Termini train station, named for "baths," is across the street, and Piazza della Repubblica, a common filming scene, is directly outside.

Santa Maria Maggiore holds sway on the Esquiline Hill, a grand building set apart by its piazza and hill. Legend says Pope Liberius received a vision in 358 to build a church where snow falls, and a miracle snow did take place, leading to this church dedicated to Mary. Inside the church is the manger of Christ. The piazza also has a large taxi St. Lawrence (Lorenzo, in Italian), was a deacon of the church who was killed on August 10, 258 in the Roman persecutions under the

The Basilica of San Sebastiano fuori le Mura sits on the Ancient Appian Way, Rome's major north-south road. Saint Sebastian, an early martyr, was killed by being tied to a tree and shot with arrows, a popular image in art. This church, one of Rome's oldest, was established under Constantine but heavily renovated. Its location near the catacombs and Appian Way makes it a worthwhile stop outside the city.