Outside of the main city of Rome, along the ancient Appian Way - the main road of Ancient Rome, sits the church of Domine Quo Vadis. The phrase comes from the legend of Peter (specifically, the apocryphal Acts of Peter) and is said to be the words that Peter spoke to the risen Christ. Peter was fleeing the persecutions of Rome, and on the way out of the city on the main road, the Appian Way, he came across the risen Christ, who was headed into Rome.

The Church of Saint Peter in Chains contains, as the name suggests, the chains that held Peter when he was imprisoned in Rome. They are prominently displayed under the altar. The story about the chains can be a bit confusing. At its core, the chain that held St. Peter was divided at some point in its history, with half going to Jerusalem. It was returned to Rome, however, and upon being placed with the other half, to two pieces joined to become one.