Outside of the main city of Rome, along the ancient Appian Way - the main road of Ancient Rome, sits the church of Domine Quo Vadis. The phrase comes from the legend of Peter (specifically, the apocryphal Acts of Peter) and is said to be the words that Peter spoke to the risen Christ. Peter was fleeing the persecutions of Rome, and on the way out of the city on the main road, the Appian Way, he came across the risen Christ, who was headed into Rome.

The Basilica of San Sebastiano fuori le Mura sits on the Ancient Appian Way, Rome's major north-south road. Saint Sebastian, an early martyr, was killed by being tied to a tree and shot with arrows, a popular image in art. This church, one of Rome's oldest, was established under Constantine but heavily renovated. Its location near the catacombs and Appian Way makes it a worthwhile stop outside the city.